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Substitution rxns

28 Aug 2022 - importance: 4

Sn1 Reactions

  • Unimolecular nucleophilic substitution
  • Step 1: LG leaves, forming carbocation
  • Step 2: nucleophile attacks from either side, forming a racemic mixture of products

Sn2 Reactions

  • Bimolecular nucleophilic substitution
  • Only 1 step
  • Nucleophile performs backside attack and LG leaves simultaneously
  • Stereochemistry is inverted
  • Prefers less-susbstituted carbons bc of steric hindrance